Genomic imprinting is an epigenetic mechanism of inheritance which allows genes to be expressed differently depending on which parent they come from. Genomic imprinting affects a subset of genes in mammals and results in a monoallelic, parental-specific expression pattern. The epigenetic phenomenon of genomic imprinting has motivated the development of numerous theories for its evolutionary origins and genomic distribution. This parent-of-origin dependent phenomenon is a notable exception to the laws of Mendelian genetics. Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. Most of these genes are located in clusters that are regulated through the use of insulators or long noncoding RNAs (lncRNAs). Genomic imprinting has provided insights into epigenetic principles that apply in many contexts. This means it is modification of the genome, or changes what the genome produces, without changing the nucleotide (DNA) sequence.

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